Strategic & coherent approach to process engineering…!!

Praj Hipurity |

Entering a Super market without first considering what you want to buy can prove costly, as people tend to buy more than they need. Similarly when discussing the purchase of customised equipment, lack of specific knowledge and a systematic approach may lead to over spending.

I'll touch on a few aspects that need to be thoroughly discussed and the pros and cons weighed before making a decision.

Closed vs Open design: The pharmaceutical industry seeks to move to fully integrated closed processing in continuous mode of operation. The goal is to remove aseptic manipulation that can cause cross- contamination, boost process efficiency, and ultimately, improve patient safety. The open design with aseptic connectors, on the other hand, gives the same level of assurance while also providing better flexibility, reduced capital expenditure, operator friendliness, etc.

Multiport valves selection: Cleanliness and drainability are two of the most important aspects of equipment design. As a result, it must be considered when designing, along with keeping dead legs to a minimum. Multiport valves provide greater flexibility, compact design and reduce dead legs. It can be used in critical areas where there is a higher risk of contamination that could compromise the product profile, such as transfer-in and transfer-out product lines when more than two valves are required. This is to ensure that rigid pipe has the least amount of dead leg as possible and other less critical locations can be achieved by installing 2 way / T-pattern valves with the appropriate slope and angle.

Optimum utility sizing: CIP and SIP are the two most important sequences in terms of water, steam, and energy consumption. Unfortunately, in most cases, it is overlooked, resulting in oversized / undersized utilities. Establishing the capacity need for clean utilities require knowledge of prospective utility usage, analysis to establish which equipment is likely to need utility at the same time and do calculation accordingly. Estimating the utility requirements for standalone equipment is generally easier, but simultaneous judgement is not!!

As long as a logical and systematic method is followed, the operator will have a sufficient utility system to ensure smooth and reliable operation.

Lastly, you can trust Team Praj Hipurity to assist you in making the best choices and designs for each of the aforementioned aspects while adhering to global quality and safety standards.